FIELD: chemistry.
SUBSTANCE: invention relates to a method for synthesis of 4(5)-(2-hetaryl) and 4(5)-(2-hetaryl)-2-(2'-hetaryl)-imidazoles of general formula 
R=2-furyl, 2-thienyl; R'H; and R=2-furyl, 2-thienyl; R'=2-furyl is obtained using 2-bromoacetylfuran (thiophene) of general formula 
2-thienyl and aldehydes in the presence of copper acetate, synthesis of a 2-bromoacetylfuran (thiophene) precursor is carried out by reacting 2-acetylfuran (thiophene) with copper (II) bromide.
EFFECT: increased safety of the process.
2 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING 2-ARYLAMINO-4-HETARYLPYRIMIDINES | 2011 |
|
RU2486180C1 |
| METHOD FOR PREPARING 3,4-DIARYL(HETARYL)MALEIMIDES | 2005 |
|
RU2278855C1 |
| METHOD OF PREPARATION OF 4-HETARYL-3,6-DIOXO-2,3,4,5,6,7-HEXAHYDROISOTHIAZOLO[5,4-b]PYRIDINE-5-CARBONITRILES | 2023 |
|
RU2812610C1 |
| COMPOUNDS OF 2-AMINOCARBOXYLIC ACID SUBSTITUTED WITH 5-ARYL- -ISOXAZOLE-4-YL AND PHARMACEUTICAL COMPOSITION ON THEIR BASE | 1994 |
|
RU2138488C1 |
| METHOD OF PREPARING BIS(5-PHENYLFUR-2-YL)METHANE DERIVATIVES | 2000 |
|
RU2165930C1 |
| METHOD OF PREPARING IMIDAZOLE DERIVATIVES | 0 |
|
SU803858A3 |
| METHOD OF PREPARING SUBSTITUTED N-/2-(FURYL-2)-ETHYL/-PROPYNYLAMINES OR THEIR SALTS, OR THEIR OPTICAL ISOMERS | 0 |
|
SU741796A3 |
| METHOD OF PRODUCING 2-HETARYL DERIVATIVES OF BENZOTHIAZOLE AND BENZOXAZOLE | 2008 |
|
RU2371442C1 |
| PYRIDONE DERIVATIVES 3-(5-((4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)CARBAMOYL)-1,3,4-THIADIAZOL-2-YL)-, 3-(5)-((6-METHYL-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDIN-3-YL)CARBAMOYL)-1,3,4-THIADIAZOL-2-YL)- AND 3-(5-((6)-METHYL-2-OXO-4-(THIOPHEN-2-YL)-1,2-DIHYDROPYRIDIN-3-YL)CARBAMOYL)-1,3,4-THIADIAZOL-2-YL)PROPIONIC ACID HAVING ANTIDIABETIC ACTIVITY AND METHOD OBTAINING THEREOF | 2023 |
|
RU2821098C1 |
| METHOD FOR SYNTHESIS OF 1-HETARYL-2-NITRO-2-(3-PHENYL-1,2,4-OXADIAZOL-5-YL)ETHANES | 2009 |
|
RU2415140C1 |
