METHOD FOR SYNTHESIS OF 1-HETARYL-2-NITRO-2-(3-PHENYL-1,2,4-OXADIAZOL-5-YL)ETHANES Russian patent published in 2011 - IPC C07D413/06 

FIELD: chemistry.

SUBSTANCE: invention relates to a method for synthesis of hetaryl derivatives of 2-nitro-2-(3-phenyl-1,2,4-oxadiazol-5-yl)-ethanes of general formula where, I a,d,i R¹=NO₂, R²=H; I b,e,k R¹=NO₂, R²=Me; I v,g,l R¹=CO₂Et, R²=H; I e,z,m R¹=CO₂Et, R²=Me; I a-r R³=piperidinyl; I d-z R³=1-pyrrolidinyl, I i-m R³=morpholinyl, based on a nucleophilic substitution reaction of terminal chlorine in 2-nitro-1-chloro-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanes of formula IV with 2,5 times excess piperdine, pyrrolidine or morpholine, while heating and stirring in dried ethanol and holding at temperature 25°C for 2 days.

EFFECT: efficient method of producing hetaryl derivatives.

1 cl, 2 tbl, 12 ex