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2 821 098

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IPC

C07D417/12(2006-01-01)

C07D417/14(2006-01-01)

A61K31/433(2006-01-01)

A61K31/4412(2006-01-01)

A61K31/4436(2006-01-01)

A61P3/10(2006-01-01)

(21) (22)

Application

2023107278, 2023-03-27

(24)

Start date

2023-03-27

(22)

Actual filing date

2023-03-27

(45)

Published

2024-06-17

(72)

Inventor

Palamarchuk Irina ValerevnaKulakov Ivan VyacheslavovichShulgau Zarina ToktamysovnaSergazy Shyngys DauletkhanulyGulyaev Aleksandr Evgenevich

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Universitet"

PYRIDONE DERIVATIVES 3-(5-((4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)CARBAMOYL)-1,3,4-THIADIAZOL-2-YL)-, 3-(5)-((6-METHYL-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDIN-3-YL)CARBAMOYL)-1,3,4-THIADIAZOL-2-YL)- AND 3-(5-((6)-METHYL-2-OXO-4-(THIOPHEN-2-YL)-1,2-DIHYDROPYRIDIN-3-YL)CARBAMOYL)-1,3,4-THIADIAZOL-2-YL)PROPIONIC ACID HAVING ANTIDIABETIC ACTIVITY AND METHOD OBTAINING THEREOF Russian patent published in 2024 - IPC C07D417/12 C07D417/14 A61K31/433 A61K31/4412 A61K31/4436 A61P3/10

Abstract RU 2821098 C1

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to compounds of formula Ia-c. Compounds are 3-(5-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)carbamoyl)-1,3,4-thiadiazol-2-yl)propionic acid (Ia), 3-(5-((6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)carbamoyl)-1,3,4-thiadiazol-2-yl)propionic acid (Ib) and 3-(5-((6-methyl-2-oxo-4-(thiophen-2-yl)-1,2-dihydropyridin-3-yl)carbamoyl)-1,3,4-thiadiazol-2-yl)propionic acid (Ic). Invention also relates to a method of producing compounds of formula Ia-c, in which thiohydrazine of oxamic acid (Va-c) is boiled with succinic anhydride in acetic acid for 4 hours.

EFFECT: obtaining compounds of formula Ia-c for use as a drug for treating diabetes.

3 cl, 2 tbl, 5 ex

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RU 2 821 098 C1

Authors

Palamarchuk Irina Valerevna

Kulakov Ivan Vyacheslavovich

Shulgau Zarina Toktamysovna

Sergazy Shyngys Dauletkhanuly

Gulyaev Aleksandr Evgenevich

Dates

2024-06-17—Published

2023-03-27—Filed