FIELD: fine organic synthesis.
SUBSTANCE: invention relates to a method of producing 4-hetaryl-3,6-dioxo-2,3,4,5,6,7-hexahydroisothiazolo[5,4-b]pyridine-5-carbonitriles of general formula 1, where R represents 2-thienyl, 2-furyl or 5-methyl-2-furyl, of interest as biocides and potential anticancer drugs. The production method involves treating 6-amino-4-hetaryl-3-carbamoyl-5-cyano-1,4-dihydropyridine-2-thiolates of triethylammonium as starting compounds, and is characterized by the fact that the reaction is carried out in the system dimethyl sulfoxide — aqueous 37% hydrochloric acid at 25°C for 5–15 minutes.
EFFECT: production of previously undescribed, partially saturated target products, and the provision of a method using non-aromatic substrates and carrying out simultaneous functionalization of the compound 1 molecule during an oxidation reaction.
1 cl, 3 ex
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