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2 400 826

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IPC

G09B23/28(2006-01-01)

A61K31/7048(2006-01-01)

A61P43/00(2006-01-01)

(21) (22)

Application

2009140129/14, 2009-10-29

(24)

Start date

2009-10-29

(22)

Actual filing date

2009-10-29

(45)

Published

2010-09-27

(72)

Inventor

Chernomortseva Elena StanislavovnaPokrovskij Mikhail VladimirovichPokrovskaja Tat'Jana Grigor'EvnaArtjushkova Elena BorisovnaBelous Aleksandr SergeevichBesedin Andrej ViktorovichKalutskij Pavel VjacheslavovichGureev Vladimir VladimirovichLitvjakova Evgenija IgorevnaLitvjakova Marija Igorevna

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet Federal'Nogo Agentstva Po Zdravookhraneniju I Sotsial'Nomu Razvitiju"

METHOD OF CORRECTING ENDOTHELIAL DYSFUNCTION WITH AZITHROMYCIN IN MODELING OF CHRONIC GRAM-POSITIVE SEPSIS Russian patent published in 2010 - IPC G09B23/28 A61K31/7048 A61P43/00

Abstract RU 2400826 C1

FIELD: medicine.

SUBSTANCE: for correction of endothelial dysfunction in experiment on rats dysfunction is modelled by preliminary sensitisation of animal with staphylococcus anatoxin in doze 0.1 ml subcutaneously. Then after 24 hours in the same place as anatoxin introduced is suspension of Staphylococcus aureus subcutaneously in dose 60 billions of microbial bodies in 1 ml. After that for following generalisation of infectious agent, daily massage of injection place is carried out. At this background introduced is macrolidal medication azithromycin intragastrically in dose 30 mg/kg/day.

EFFECT: method ensures activation of endothelial dysfunction correction.

1 ex, 1 tbl

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RU 2 400 826 C1

Authors

Chernomortseva Elena Stanislavovna

Pokrovskij Mikhail Vladimirovich

Pokrovskaja Tat'Jana Grigor'Evna

Artjushkova Elena Borisovna

Belous Aleksandr Sergeevich

Besedin Andrej Viktorovich

Kalutskij Pavel Vjacheslavovich

Gureev Vladimir Vladimirovich

Litvjakova Evgenija Igorevna

Litvjakova Marija Igorevna

Dates

2010-09-27—Published

2009-10-29—Filed