MIDECAMYCIN-BASED CORRECTION MODE OF ENDOTHELIAL DYSFUNCTION ASSOCIATED WITH L-NAME-INDUCED NITROGEN OXIDE DEFICIENCY Russian patent published in 2009 - IPC A61K31/7048 A61K31/221 A61P9/00 

Abstract RU 2353370 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to experimental cardiopharmacology and can be used for correction of endothelial dysfunction in experiment ensured by modelling endothelial dysfunction in laboratory animals during 7 days through daily intraperitoneal introduction of L-nitro-arginine-methyl ester dosed 25 mg/kg and followed with endogastric introduction of macrolide Midecamycin in single dose 10 and 30 mg/kg a day.

EFFECT: method ensures effective correction of endothelial dysfunction due to anti-oxidant action of Midecamycin.

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RU 2 353 370 C1

Authors

Chernomortseva Elena Stanislavovna

Pokrovskij Mikhail Vladimirovich

Pokrovskaja Tat'Jana Grigor'Evna

Kharchenko Aleksandr Vladimirovich

Artjushkova Elena Borisovna

Gasanov Melik Tofikovich

Najmushina Marija Aleksandrovna

Goncharova Sofija Vladimirovna

Martynova Ol'Ga Ivanovna

Kljavs Petr Janovich

Chueva Tat'Jana Vladimirovna

Poljanichko Natal'Ja Vladislavovna

Drobyshevskaja Olesja Pavlovna

Stasjuk Ljudmila Vital'Evna

Kochubej Sofija Jur'Evna

Blashchenko Ekaterina Konstantinovna

Volkova Natal'Ja Sergeevna

Karadzhaev Timur Binal'Evich

Dates

2009-04-27Published

2007-11-22Filed