FIELD: medicine.
SUBSTANCE: method involves simulating gestosis in Wistar rats by the daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg for 7 days. That is followed by the intragastric introduction of azithromycin 30 mg/kg once a day in the setting of the model above from 14th to 20th day of pregnancy.
EFFECT: method provides the manifested endothelial dysfunction correction in the special pathogenesis environment in the pregnant females in a combination with eliminating acute infectious diseases or aggravated chronic infectious processes that can also lead to the formation of gestosis.
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