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2 401 304

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IPC

C12N15/00(2006-01-01)

C12N15/70(2006-01-01)

C12N1/21(2006-01-01)

C12P21/00(2006-01-01)

C12P21/08(2006-01-01)

G01N33/53(2006-01-01)

(21) (22)

Application

2008146599/10, 2008-11-26

(24)

Start date

2008-11-26

(22)

Actual filing date

2008-11-26

(45)

Published

2010-10-10

(72)

Inventor

Sharapova Natal'Ja Evgen'EvnaLunin Vladimir GlebovichVerkhovskaja Ljudmila ViktorovnaAnan'Ina Julija Vasil'EvnaGintsburg Aleksandr Leonidovich

(73)

Holder

Gosudarstvennoe Uchrezhdenie Nauchno-Issledovatel'Skij Institut Ehpidemiologii I Mikrobiologii Imeni Pochetnogo Akademika N.F. Gamalei Rossijskoj Akademii Meditsinskikh Nauk

RECOMBINANT PLASMID pD5spGBD, Escherichia coli STRAIN - RECOMBINANT PROTEIN D5-GBD PRODUCER, RECOMBINANT PROTEIN D5-GBD AND METHOD FOR MAKING THEREOF, METHOD FOR STUDYING PROTEIN D5-GBD FIXATION TO SERUM ANTIBODIES, METHOD FOR MAKING SPECIFIC PROTEIN D5-GBD ANTIBODIES Russian patent published in 2010 - IPC C12N15/00 C12N15/70 C12N1/21 C12P21/00 C12P21/08 G01N33/53 

Abstract RU 2401304 C2

FIELD: medicine.

SUBSTANCE: invention represents plasmid DNA pD5spGBD enabling the expression of a recombinant antigen - protein LigA L. interrogans domain 5 in chimeric protein D5-GBD and 1,3-β-glucan-binding domain (GBD), and a method for making a based subunit engineered leptospirosis vaccine.

EFFECT: invention allows ensuring the development of an intensive immune response and high level of antibodies synthesis with no additional adjuvants.

6 cl, 1 dwg, 6 ex

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RU 2 401 304 C2

Authors

Sharapova Natal'Ja Evgen'Evna

Lunin Vladimir Glebovich

Verkhovskaja Ljudmila Viktorovna

Anan'Ina Julija Vasil'Evna

Gintsburg Aleksandr Leonidovich

Dates

2010-10-10—Published

2008-11-26—Filed

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