FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to gene engineering, biochemistry, biotechnology and immunology, and represents recombinant plasmid pESAT6-CFP10-DBD, recombinant strain Escherichia coli M15 [pREP4, pESAT6-CFP10-DBD], a method for preparing, immobilising, concentrating and purifying recombinant protein ESAT6-CFP10-DBD on dextran, recombinant protein ESAT6-CFP10-DBD with molecular weight 26.4 kDa, an immunogenic composition containing protein ESAT6-CFP10-DBD immobilised on dextran, specifically activating T-lymphocytes synthesising IFN-gamma with antigen stimulation of mycobacteria.
EFFECT: invention enables ensuring the high level of protein expression, which induces the immune response to mycobacterial antigen effectively.
5 cl, 2 dwg, 1 tbl, 5 ex
| Title |
Year |
Author |
Number |
| METHOD FOR OBTAINING IMMUNOGENIC COMPOSITION BASED ON CFP10-DBD HYBRID PROTEIN AND DEXTRANE; pCFP10-DBD RECOMBINANT PLASMIDE; Escherichia coli [pREP4, pCFP10-DBD] STRAIN; CFP10-DBD CHIMERIC PROTEIN AND THEIR APPLICATION |
2013 |
- Tkachuk Artem Petrovich
- Ljashchuk Aleksandr Mikhajlovich
- Aksenova Ekaterina Ivanovna
- Poletaeva Nina Nikolaevna
- Galushkina Zoja Mikhajlovna
- Sergienko Ol'Ga Vasil'Evna
- Kondrat'Eva Tat'Jana Konstantinovna
- Apt Aleksandr Solomonovich
- Erokhin Vladislav Vsevolodovich
- Karjagina-Zhulina Anna Stanislavovna
- Lunin Vladimir Glebovich
- Gintsburg Aleksandr Leonidovich
|
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2013 |
- Tkachuk Artem Petrovich
- Ljashchuk Aleksandr Mikhajlovich
- Aksenova Ekaterina Ivanovna
- Poletaeva Nina Nikolaevna
- Galushkina Zoja Mikhajlovna
- Sergienko Ol'Ga Vasil'Evna
- Apt Aleksandr Solomonovich
- Karjagina-Zhulina Anna Stanislavovna
- Lunin Vladimir Glebovich
- Gintsburg Aleksandr Leonidovich
|
RU2520737C1 |
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2013 |
- Tkachuk Artem Petrovich
- Ljashchuk Aleksandr Mikhajlovich
- Aksenova Ekaterina Ivanovna
- Poletaeva Nina Nikolaevna
- Galushkina Zoja Mikhajlovna
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|
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2010 |
- Aksenova Ekaterina Ivanovna
- Ljashchuk Aleksandr Mikhajlovich
- Sergienko Ol'Ga Vasil'Evna
- Galushkina Zoja Mikhajlovna
- Poletaeva Nina Nikolaevna
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- Lunin Vladimir Glebovich
- Gintsburg Aleksandr Leonidovich
|
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2010 |
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- Ljashchuk Aleksandr Mikhajlovich
- Sergienko Ol'Ga Vasil'Evna
- Galushkina Zoja Mikhajlovna
- Poletaeva Nina Nikolaevna
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2010 |
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- Ljashchuk Aleksandr Mikhajlovich
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2014 |
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2018 |
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