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2 499 048

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C1

(51)

IPC

C12N15/63(2006-01-01)

(21) (22)

Application

2012140616/10, 2012-09-24

(24)

Start date

2012-09-24

(22)

Actual filing date

2012-09-24

(45)

Published

2013-11-20

(72)

Inventor

Sharapova Natal'Ja Evgen'EvnaKotnova Alina PetrovnaSergienko Ol'Ga Vasil'EvnaGalushkina Zoja MikhajlovnaPoletaeva Nina NikolaevnaLavrova Natal'Ja Vital'EvnaGrunina Tat'Jana MikhajlovnaLjashchuk Aleksandr MikhajlovichSemikhin Aleksandr SergeevichGromov Aleksandr ViktorovichBartov Mikhail SergeevichSubbotina Marina Evgen'EvnaKarpova Tat'Jana AndreevnaErshova Anna StepanovnaLunin Vladimir GlebovichKarjagina-Zhulina Anna StanislavovnaGintsburg Aleksandr Leonidovich

(73)

Holder

Rossijskaja Federatsija, Ot Imeni Kotoroj Vystupaet Ministerstvo Promyshlennosti I Torgovli Rossijskoj Federatsii Rossii)Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Institut Ehpidemiologii I Mikrobiologii Imeni Pochetnogo Akademika N.F. Gamalei" Ministerstva Zdravookhranenija Rossijskoj Federatsii Im. N.F. Gamalei" Minzdrava Rossii).

RECOMBINANT PLASMID, RECOMBINANT STRAIN, RECOMBINANT PROTEIN BMP-2 AND EXTRACTION METHOD OF RECOMBINANT PROTEIN IN DIMERIC FORM Russian patent published in 2013 - IPC C12N15/63 

Abstract RU 2499048 C1

FIELD: biotechnologies.

SUBSTANCE: invention represents recombinant BMPRIA-CBD plasmid, and E.coli strain transformed with that plasmid. The invention also refers to recombinant BMPRIA-CBD protein that is used for production of BMP-2 protein.

EFFECT: invention allows producing chromatographic clean fractions of biologically active dimeric form of BMP-2 protein, which can be used as osteoinductive components of osteoplastic materials of new generation.

4 cl, 2 dwg, 6 ex

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RU 2 499 048 C1

Authors

Sharapova Natal'Ja Evgen'Evna

Kotnova Alina Petrovna

Sergienko Ol'Ga Vasil'Evna

Galushkina Zoja Mikhajlovna

Poletaeva Nina Nikolaevna

Lavrova Natal'Ja Vital'Evna

Grunina Tat'Jana Mikhajlovna

Ljashchuk Aleksandr Mikhajlovich

Semikhin Aleksandr Sergeevich

Gromov Aleksandr Viktorovich

Bartov Mikhail Sergeevich

Subbotina Marina Evgen'Evna

Karpova Tat'Jana Andreevna

Ershova Anna Stepanovna

Lunin Vladimir Glebovich

Karjagina-Zhulina Anna Stanislavovna

Gintsburg Aleksandr Leonidovich

Dates

2013-11-20—Published

2012-09-24—Filed

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