RECOMBINANT PLASMID, RECOMBINANT STRAIN, RECOMBINANT PROTEIN BMP-2 AND EXTRACTION METHOD OF RECOMBINANT PROTEIN IN DIMERIC FORM Russian patent published in 2013 - IPC C12N15/63 

Abstract RU 2499048 C1

FIELD: biotechnologies.

SUBSTANCE: invention represents recombinant BMPRIA-CBD plasmid, and E.coli strain transformed with that plasmid. The invention also refers to recombinant BMPRIA-CBD protein that is used for production of BMP-2 protein.

EFFECT: invention allows producing chromatographic clean fractions of biologically active dimeric form of BMP-2 protein, which can be used as osteoinductive components of osteoplastic materials of new generation.

4 cl, 2 dwg, 6 ex

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RU 2 499 048 C1

Authors

Sharapova Natal'Ja Evgen'Evna

Kotnova Alina Petrovna

Sergienko Ol'Ga Vasil'Evna

Galushkina Zoja Mikhajlovna

Poletaeva Nina Nikolaevna

Lavrova Natal'Ja Vital'Evna

Grunina Tat'Jana Mikhajlovna

Ljashchuk Aleksandr Mikhajlovich

Semikhin Aleksandr Sergeevich

Gromov Aleksandr Viktorovich

Bartov Mikhail Sergeevich

Subbotina Marina Evgen'Evna

Karpova Tat'Jana Andreevna

Ershova Anna Stepanovna

Lunin Vladimir Glebovich

Karjagina-Zhulina Anna Stanislavovna

Gintsburg Aleksandr Leonidovich

Dates

2013-11-20Published

2012-09-24Filed