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(19)

RU

(11)

2 662 558

(13)

C2

(51)

IPC

A61K9/00(2006-01-01)

A61K39/395(2006-01-01)

A61K47/12(2006-01-01)

A61K47/36(2006-01-01)

(21) (22)

Application

2016105462, 2014-07-21

(24)

Start date

2014-07-21

(22)

Actual filing date

2014-07-21

(45)

Published

2018-07-26

(72)

Inventor

Krontkhaler UlrikhFirtlbek-Shudi MargoBaron Melani

(73)

Holder

Kheksal Ag

METHODS AND COMPOSITIONS WHICH ALLOW MODULATION OF IMMUNE RESPONSES RELATED TO ADMINISTRATION OF BIOPHARMACEUTICAL DRUG Russian patent published in 2018 - IPC A61K9/00 A61K39/395 A61K47/12 A61K47/36 

Abstract RU 2662558 C2

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to a method for preparing a pharmaceutical composition comprising an anti-TNFα antibody, a method for using hexanedioic acid to modulate the immunogenicity of a pharmaceutical composition, as well as a pharmaceutical composition and a method for modulating immune responses. Composition comprises an anti-TNFα antibody buffer comprising hexanedioic acid or at least one salt thereof and/or citric acid or at least one salt thereof.

EFFECT: modulation of immune responses related to the administration of a biopharmaceutical drug.

18 cl, 4 tbl, 2 ex, 6 dwg

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RU 2 662 558 C2

Authors

Krontkhaler Ulrikh

Firtlbek-Shudi Margo

Baron Melani

Dates

2018-07-26—Published

2014-07-21—Filed

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