FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to medicinal agents and method for increasing biological availability of renin inhibitor, consisting in the fact that to mammal in need of such treatment, combination containing renin inhibitor and exhaustive protein inhibitor is jointly administered, in which inhibitor of exhaustive protein represents inhibitor MDR1, such as PSC833, and renin inhibitor represents derivative of amide δ-amino-γ-hydroxy-ω-arylalkanoic acid, with formula of 
(I), where R1, R2, R3 and R4 have values specified in the formula.
EFFECT: production of pharmaceutical composition, having hypotensive effect, containing renin inhibitor in therapeutically efficient amount in combination with inhibitor of exhaustive protein, and application of exhaustive protein inhibitor for preparation of medicinal agent intended to increase biological availability of renin inhibitor.
21 cl, 5 dwg, 5 ex
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