BICYCLIC TETRAHYDROPYRAZOLEPYRIDINES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITION, METHOD OF PHOSPHODIESTERASE INHIBITION, METHOD OF PATIENT TREATMENT Russian patent published in 1999 - IPC

FIELD: organic chemistry, biochemistry, medicine, pharmacy. SUBSTANCE: invention relates to bicyclic tetrahydropyrazole- -pyridines of the formula (I) where R¹ is C_1-3-alkyl; X - oxygen atom or two hydrogen atoms; R² is C_1-4-alkyl, indalyl, C_3-7-cycloalkyl or the group of the formula (II) ; a = 1 or 2; b and c = 0 or 1; R⁴ - H, C_1-5-alkyl, alkoxyl, C_3-6-cyclo- -alkoxyl, halogen atom, CF₃, CO₂R₆, CONR⁶R⁷, NR⁶R⁷; R⁶, R⁷ - H or C_1-4-alkyl; Z is SO; Y is C_1-5-alkylene; R³ has values indicated for R² and methylenecyclopropyl at condition that R² and R³ can not mean simultaneously methyl, or their pharmaceutically acceptable salts and a pharmaceutical composition based on said that inhibit activity of phosphodiesterase of type-IV and production of tumor necrosis factor. EFFECT: enhanced effectiveness of compounds and composition as inhibitors of phosphodiesterase, improved method of treatment. 8 cl, 7 tbl, 39 ex