METHOD OF PREDICTING PROSTHESIS INSTABILITY IN ENDOPROSTHETICS OF LARGE JOINTS Russian patent published in 2010 - IPC A61B10/00 G01N33/50 

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to traumatology, orthopedics and immunology. In order to predict prosthesis instability in endoprosthetics of large joints, analysis of immunologic parametres in patient's peripheral bloodbefore operation is carried out. Cells of peripheral blood are incubated without stimulation with mitogen and with stimulation with bacterial lipopolysaccharide. In obtained supernatants concentration of TNF-a (Tumor Necrosis Factor-α) is determined. Stimulation index is determined by ratio of stimulated TNF-α product to its spontaneous level. If determined index value is higher than 2.5 high risk of development of instability of endoprosthesis components is predicted.

EFFECT: method allows to increase objectivity of prediction of development of prosthesis instability due to earlier determination of individual immunologic reactivity of organism to damaging factors of various types and to perform immunologic rehabilitation of patients in due time, as well as to simplify technology of prediction and reduce multiplicity of laboratory reaseach.

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