FIELD: chemistry.
SUBSTANCE: present invention relates to a method for synthesis of tritium-labelled 2-phenyl substituted isoquinoline derivatives of general formula: 
, according to which isoquinoline undergoes a reaction for direct phenylation of a nitrogen atom with nucleogenic free phenyl cations. The source of pheny cations is a hexane solution twice titrated with benzene and the process is carried out in a closed system in the presence of a strong stabilising anion of potassium tetrafluoroborate.
EFFECT: novel single-step method for synthesis of tritium-labelled 2-phenyl substituted isoquinoline derivatives.
1 cl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING N-PHENYL-SUBSTITUTED TRICYCLIC NITROGEN COMPOUNDS LABELLED WITH TRITIUM | 2010 |
|
RU2439059C1 |
| METHOD FOR PREPARING PHENYL-SUBSTITUTED DERIVATIVES OF PYRIDINE LABELED WITH TRITIUM | 2005 |
|
RU2296752C1 |
| METHOD OF PRODUCING DITRITIUM DIFLUOROBENZENE SOURCE OF FLUORINATED NUCLEOGENIC PHEHYL CATIONS | 2012 |
|
RU2479561C1 |
| TRITIUM LABELED N-PHENYLLEPIDINE SALTS AND WAY OF THEIR PRODUCTION | 2010 |
|
RU2442776C1 |
| CHEMONUCLEAR METHOD OF PRODUCING TRITIUM-LABELLED QUATERNISED STRUCTURES OF DIAZINE SERIES | 2013 |
|
RU2527115C1 |
| METHOD OF PRODUCING FLUORINE-CONTAINING QUINOLINE DERIVATIVES | 2014 |
|
RU2577531C2 |
| TRITIUM LABELED N-PHENYLQUINOLINIUM AND QUINALDINIUM SALTS AND METHOD FOR THEIR PREPARING | 2006 |
|
RU2320647C1 |
| TETRAPHENYLPHOSPHONIUM CHLORIDE LABELLED WITH TRITIUM AS INDICATOR TO MEMBRANE POTENTIAL | 0 |
|
SU1217861A1 |
| METHOD OF PRODUCING COLLOIDALLY STABLE DISPERSION OF ELECTROCONDUCTIVE POLYMER | 2006 |
|
RU2359349C2 |
| SYNTHESIS OF TRITIUM-LABELED 6,7-DIMETHOXY-4,4-DIMETHYL-1-[4-(4-TRIFLUOROMETHYLPHENOXY)PHENYL]-3N-ISOQUINOLINE | 2019 |
|
RU2711646C1 |
