METHOD FOR PREPARING PHENYL-SUBSTITUTED DERIVATIVES OF PYRIDINE LABELED WITH TRITIUM Russian patent published in 2007 - IPC C07D213/20 C07D213/24 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for preparing N-phenylpicolinium salts and phenyl-substituted picolines labeled with tritium by phenyl ring of the general formula: [CH₃C₅H₄N⁺C₆H^* ₅]BF^- ₄ and CH₃C₆H^* ₅C₅H₃N. Method involves arylation of 2-, 3- and 4-picolines with free phenyl cations obtained in beta-decay of tritium in composition of two-fold labeled benzene in the presence of potassium tetrafluoroborate in the closed system. Method provides improving method of synthesis of labeled benzene and to use ion-molecular reaction of tritium-labeled phenyl cations for simultaneous, simple and a single-step synthesis of N-phenylpicolinium salts and phenyl-substituted picolines labeled with tritium that can be used in investigations of metabolism of biologically active heterocyclic derivatives.

EFFECT: improved method of synthesis.

1 dwg, 1 ex