FIELD: chemistry.
SUBSTANCE: there is described a method for synthesis of protected DO3A, such as DO3A-tri-tert-butyl ether (tri-tert-butyl ether of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid) of formula 
, where R denotes tert-butyl; X is a chloride, bromide or iodide anion; y equals 1, by reacting cyclene and activated acetic ester of formula 
in the presence of a polar solvent mixed with water, and then addition of KBr at pH 9.0±0.5. The end product has high degree of purity.
EFFECT: improved method for synthesis of protected DO3A.
8 cl, 2 ex
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