CYCLIC POLYAMINE CONTAINING NITROGEN ATOMS N IN RING PROTECTED BY PRINCIPLE "ALL EXCEPT ONE (N-1)" AND METHODS FOR THEIR PREPARING Russian patent published in 2007 - IPC C07D257/02

Abstract RU 2311413 C2

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention describes novel cyclic polyamines of the following formulae: (XIV): wherein y = 1-5; p = 0; z = 3-11; m and m' are similar and mean a whole number from 0 to 2; n and n' are similar and mean a hole number from 1 to 2; E means hydrogen atom, phenylaminocarbonyl, benzyloxycarbonyl or toluenesulfonyl; Ar means 1,4-phenylene-bis-(C₁-C₂)-alkylene. Also, invention relates to methods for synthesis of these compounds providing protection of nitrogen atoms N by principle "(N-1)" with the high yield, i. e. all are protected except for one amino-group by using the specific perfluoro-containing agents that provides in subsequent light removal of protection. Also, invention discloses a novel method for synthesis of 1,1'-[1,4-phenylene-bis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane possessing anti-HIV activity.

EFFECT: improved methods of synthesis, valuable antiviral properties of compounds.

22 cl, 3 dwg, 11 ex

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RU 2 311 413 C2

Authors

Dzhandomeniko Kristen M.

Jang Ven

Dates

2007-11-27—Published

2001-09-28—Filed