CASCADE POLYMER COMPLEXES, DIAGNOSTIC CONTRAST SUBSTANCE CONTAINING THEREOF, AND INTERMEDIATES Russian patent published in 2003 - IPC

FIELD: medical-destination polymers. SUBSTANCE: invention provides cascade polymer complexes containing (i) complexing ligands of general formula I: A-[X-{Y-[Z-(W-K_w)_z]_y}_x]_a, wherein A, Z, W, X, a, z, w, x, and y are specified in claims, K denotes complexing agent residue of formula IA: R¹ (IA), in which R² and R³ represent hydrogen, -CH(R⁴)-CO-N(R²)-U⁷-T- group R⁴, U⁷ hydrogen or C1-C30-alkyl, -CO-α saturated C1-C20-alkylene group, and T represents α with denoting connection site between terminal nitrogen atoms of the last generation of reproductive monomer unit W, or K denotes complexing agent residue of formula IB: R¹ with α representing hydrogen and being as indicated above, on condition that at least two reproductive monomer units, product of multipleticity coefficients a*x*y*z*w is equal to 24 or 36; (ii) at least 19 ions of elements selected from lanthanoids; and, if necessary, (ii) acylated terminal amino groups. Invention further describes diagnostic contrast substance containing above-indicated polymers and also describes 1,4,7.10-tetracyclodecane derivatives as intermediates in synthesis of these polymers. EFFECT: extended choice of diagnostic contrast substances. 5 cl, 1 dwg, 9 ex