FIELD: organic chemistry, pharmacy.
SUBSTANCE: invention describes perfluoroalkyl-containing metallic complexes of the general formula (I): RF-L-A wherein RF represents perfluorinated, direct or branched carbon chain -CnF2nX wherein X means terminal fluorine, chlorine, bromine, iodine or hydrogen atom; n means number from 4 to 30; L means a direct bond, methylene group, group -NHCO, group of the formula:
wherein p means number from 0 to 10; q and u mean independently of one another numbers 0 or 1; R1 means hydrogen atom, methyl group, group -CH2-OH-, -CH2-CO2H-, or (C2-C15)-chain that is broken, if necessary, by 1-3 oxygen atoms, 1-2>CO-groups or phenyl group substituted optionally with 1-2 carboxyl groups and/or substituted with 1-4 hydroxy-groups, 1-2 (C1-C4)-alkoxy-groups, 1-2 carboxyl groups, group -SO3H-, or it represents direct, branched, saturated or unsaturated (C2-C30)-carbon chain comprising possibly 1-10 oxygen atoms, 1-3 NR'-groups, 1-2 sulfur atoms, piperazine, -CONR'-group, -NR'CO-group, group SO2, group -NR'CO2, 1-2 CO-groups, group -CO-N-T-N(R')-SO2-RF, phenyl group substituted possibly with 1-2 carboxyl groups, and/or it is broken by these groups, and/or substituted possibly with 1-3 OR'-groups, 1-2 oxo-groups, 1-2 NH-COR'-groups, 1-2 CONHR'-groups, 1-2 (CH2)p-CO2H-groups, 1-2 groups -(CH2)p-(O)q-CH2-CH2RF wherein R1, RF and p and q have above given values, and T means (C2-C10)-chain that is broken, if necessary, by 1-2 oxygen atoms or 1-2 -NHCO-groups; A represents different metallic complexes or their salts of organic and/or inorganic bases or amino acids, or amino acid amides. Invention relates to methods for their preparing and pharmaceutical agent containing thereof as contrasting substances in vivo in nuclear spinthomography (MPT), as agent of blood-storing organs preferably and as lymphographic agent.
EFFECT: improved preparing method, valuable medicinal properties of compounds.
10 cl, 5 tbl, 5 dwg, 49 ex
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