FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to an isolated orthorhombic crystalline form of compound 4-{6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy}-butyric acid providing the excellent solubility and wherein this form is free from monoclinic crystalline forms based on data of roentgen rays diffraction on powder (XRPD) showing absence of doublet peaks between 11.5 and 16 (by 2-Theta scale) and elicits two-fold more solubility at 30°C in aqueous ethyl alcohol as compared with monoclinic crystalline form. Compound possesses oral activity in treatment of asthma and allergic diseases. Also, invention describes a pharmaceutical composition based on above said compound.
EFFECT: improved and valuable physical and medicinal properties of form.
6 cl, 1 tbl, 9 dwg, 10 ex
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