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2 405 834

(13)

(51)

IPC

C12P19/54(2006-01-01)

C12Q1/00(2006-01-01)

C12R1/32(2006-01-01)

(21) (22)

Application

2009118972/10, 2009-05-19

(24)

Start date

2009-05-19

(22)

Actual filing date

2009-05-19

(45)

Published

2010-12-10

(72)

Inventor

Evglevskij Anatolij AlekseevichKolomiets Vladislav MikhajlovichEvglevskij Dmitrij Anatol'EvichKolomiets Igor' Vladislavovich

(73)

Holder

Federal'Noe Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Kurskaja Gosudarstvennaja Sel'Skokhozjajstvennaja Akademija Imeni Professora I.I. IvanovaGosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Kurskij Gosudarstvennyj Meditsinskij Universitet Roszdrava

METHOD OF INCREASING ACTIVITY OF STREPTOMYCIN ANTIBIOTIC TOWARDS STREPTOMYCIN-RESISTANT M TUBERCULOSIS Russian patent published in 2010 - IPC C12P19/54 C12Q1/00 C12R1/32

Abstract RU 2405834 C1

FIELD: chemistry.

SUBSTANCE: method of increasing activity of streptomycin antibiotic towards streptomycin-resistant M. tuberculosis involves polymerisation and detoxification of streptomycin by treating with 0.15±0.05% formalin solution at 40.0±2.0°C for 5-7 days. Use of streptomycin antibiotic preparations obtained using disclosed method enables to lower concentration of formalin in lyophilisated form to 0.01% without changing concentration of the antibiotic.

EFFECT: high effectiveness of treating tuberculosis caused by streptomycin-resistant M tuberculosis.

1 tbl

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RU 2 405 834 C1

Authors

Evglevskij Anatolij Alekseevich

Kolomiets Vladislav Mikhajlovich

Evglevskij Dmitrij Anatol'Evich

Kolomiets Igor' Vladislavovich

Dates

2010-12-10—Published

2009-05-19—Filed