FIELD: medicine.
SUBSTANCE: method consists in detoxification and polymerization of kanamycin within sequential processing by 0.2±0.05 % formalin at 40.0±2.0°C for 3-5 days, and then by 0.2+0.05 % aethonium at 40.0±2.0°C for 3-5 days at the antibiotic content 100-150 mg/ml.
EFFECT: use of the method allows reducing toxicity of kanamycin, providing higher antibacterial activity and stability to enzymatic action of microorganism that as a whole improves therapeutic efficacy of kanamycin with respect to tuberculosis mycobacteria.
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Authors
Dates
2011-08-20—Published
2010-04-21—Filed