METHOD FOR ENSURING HIGHER EFFICACY OF KANAMYCIN WITH RESPECT TO KANAMYCIN-RESISTANT TUBERCULOSIS MYCOBACTERIA Russian patent published in 2011 - IPC C12P1/00 A61K31/00 A61P31/06 

Abstract RU 2426789 C1

FIELD: medicine.

SUBSTANCE: method consists in detoxification and polymerization of kanamycin within sequential processing by 0.2±0.05 % formalin at 40.0±2.0°C for 3-5 days, and then by 0.2+0.05 % aethonium at 40.0±2.0°C for 3-5 days at the antibiotic content 100-150 mg/ml.

EFFECT: use of the method allows reducing toxicity of kanamycin, providing higher antibacterial activity and stability to enzymatic action of microorganism that as a whole improves therapeutic efficacy of kanamycin with respect to tuberculosis mycobacteria.

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RU 2 426 789 C1

Authors

Evglevskij Anatolij Alekseevich

Evglevskij Dmitrij Anatol'Evich

Timkova Elena Anatol'Evna

Dates

2011-08-20Published

2010-04-21Filed