FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry and represents a method for increasing streptomycin activity on streptomycin-resistant tuberculosis mycobacteria consisting in the fact that streptomycin detoxification and polymerisation are conducted at first in 0.15±0.05% glutaric aldehyde at 38±40°C for 2-3 days, and then in 0.1% aethonium or 0.1% alkyldimethylbenzene ammonium chloride or 0.1% Biopague D at 38-40°C for 2-3 days at 100-150 mg/ml of the antibiotic.
EFFECT: invention provides higher efficacy and lower toxicity of the antibiotics.
3 ex
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Authors
Dates
2013-03-10—Published
2011-10-07—Filed