METHOD FOR INCREASING STREPTOMYCIN ACTIVITY ON STREPTOMYCIN-RESISTANT TUBERCULOSIS MYCOBACTERIA Russian patent published in 2013 - IPC A61K31/63 A61P31/06 

Abstract RU 2477135 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry and represents a method for increasing streptomycin activity on streptomycin-resistant tuberculosis mycobacteria consisting in the fact that streptomycin detoxification and polymerisation are conducted at first in 0.15±0.05% glutaric aldehyde at 38±40°C for 2-3 days, and then in 0.1% aethonium or 0.1% alkyldimethylbenzene ammonium chloride or 0.1% Biopague D at 38-40°C for 2-3 days at 100-150 mg/ml of the antibiotic.

EFFECT: invention provides higher efficacy and lower toxicity of the antibiotics.

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RU 2 477 135 C1

Authors

Evglevskij Anatolij Alekseevich

Kolomiets Vladislav Mikhajlovich

Evglevskij Dmitrij Anatol'Evich

Kolomiets Igor' Vladislavovich

Khudjakov Sergej Ivanovich

Timkova Elena Anatol'Evna

Dates

2013-03-10Published

2011-10-07Filed