FIELD: chemistry; biochemistry.
SUBSTANCE: invention relates to biotechnology and is in form of isolated monoclonal antibodies, particularly human monoclonal antibodies which specifically bond with PD-1 with high efficiency. The invention also relates to molecules of nucleic acids which code the disclosed antibodies, expressed by vectors which contain such nucleic acids, as well as to host cells containing said vector. The invention also relates to methods of increasing immunoreaction, inhibiting cell growth, as well as treatment of infectious diseases in a person using the disclosed antibodies.
EFFECT: disclosed antibodies enable to carry out immunotherapy when treating human diseases and reducing their side effects.
10 cl, 100 dwg, 8 tbl, 25 ex
| Title |
Year |
Author |
Number |
| HUMAN MONOCLONAL ANTIBODIES AGAINST PROGRAMMED DEATH 1 (PD-1) PROTEIN AND CANCER TREATMENT METHOD USING ANTI-PD-1-ANTIBODIES SEPARATELY OR COMBINED WITH OTHER IMMUNOTHERAPEUTIC AGENTS |
2013 |
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|
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2016 |
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|
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2006 |
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|
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2014 |
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2018 |
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2016 |
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2016 |
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2019 |
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2019 |
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