HUMAN MONOCLONAL ANTIBODIES TO THE PROTEIN OF PROGRAMMED DEATH 1 (PD-1) AND METHODS OF TREATING CANCER USING ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTIC AGENTS Russian patent published in 2020 - IPC A61K39/395 C07K16/28 C12Q1/68 C12N15/09 C12Q1/02 C12N5/00 C12P21/08 

Abstract RU 2732924 C2

FIELD: biotechnology.

SUBSTANCE: described is a method of treating an infectious disease in a subject, a method for modifying an immune response to an infectious agent in a subject and a method of activating T-cell responses to an infectious agent in a subject. Above methods are implemented with participation of an antibody or its antigen-binding part containing: Heavy chain CDR1 containing amino acids, having sequence given in SEQ ID NO: 15–21; CDR2 heavy chain containing amino acids having a sequence given in SEQ ID NO: 22–28; CDR3 heavy chain containing amino acids, having sequence given in SEQ ID NO: 29–35; CDR1 light chain containing amino acids having the sequence given in SEQ ID NO: 36–42; Light chain CDR2 containing amino acids, having sequence given in SEQ ID NO: 43–49; and light chain CDR3 containing amino acids having the sequence given in SEQ ID NO: 50–56.

EFFECT: invention extends the range of products for treating infectious diseases.

19 cl, 54 dwg, 7 tbl, 24 ex

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RU 2 732 924 C2

Authors

Korman Alan Dzh.

Srinivasan Mokhan

Van Chanyuj

Selbi Mark Dzh.

Chen Bin

Kardarelli Zhozefin M.

Dates

2020-09-24Published

2016-08-18Filed