BENZOTHIAZINE DERIVATIVES, PRODUCTION AND USE THEREOF AS MEDICAL DRUGS Russian patent published in 2014 - IPC C07D275/06 C07D417/10 C07D417/12 A61K31/5415 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to benzothiazine derivatives represented by general formula (I): 0, where R₁ is a hydrogen atom; C₁-C₆ alkyl; COR₅; SO₂R₅; CO(CH₂)_mOR₆; (CH₂)_mR₆; (CH₂)_mCONR₇R₈; (CH₂)_nNR₇R₈; (CH₂)_nOR₆; CHR₇OR₉; (CH₂)_mR₁₀; m assumes values from 1 to 6; n assumes values from 2 to 6; R₂ is phenyl; naphthyl, 1,2,3,4-tetrahydro-naphthalene, biphenyl, phenylpyridine or a benzene ring condensed with a saturated or unsaturated monocyclic heterocycle containing 5-7 atoms and consisting of carbon atoms and 1-4 heteroatoms selected from N, O or S, other than indole, R₃ is methyl or ethyl; R₄ and R′₄ are identical or different and denote a hydrogen atom; a halogen atom; C₁-C₆ alkyl; NR₇R₈; SO₂Me; as well as stereoisomers, salts and solvates thereof, for therapeutic use and which are capable of inhibiting 11β-HSD1 on an enzymatic and cellular level.

EFFECT: obtaining benzothiazine derivatives.

17 cl, 197 ex