COMPOUNDS AND COMPOSITIONS AS MODULATORS OF ACTIVATED RECEPTORS OF PEROXISOME PROLIFERATOR Russian patent published in 2011 - IPC C07D277/36 C07D277/24 C07D417/04 C07D277/26 C07D417/14 A61K31/426 A61K31/427 A61P9/10 A61P3/10 A61P25/28 

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to compounds of formula I and to their pharmaceutically acceptable salts. In formula I p is integer, equal to 0-1; L² is selected from group including -XOX-, -XSX- and -XSXO-; where X is independently selected from group, including bond and C₁-C₄alkylene; R¹³ is selected from group, including halogen, C₁-C₆alkyl, C₁-C₆alkoxygroup, -C(O) C₁-C₆alkyl; R¹⁴ is selected from group, including -XOXC(O)OR¹⁷ and -C₁-C₄alkylene-C(O)OR¹⁷; where X represents bond or C₁-C₄alkylene; and R¹⁷ is selected from group, including hydrogen and C₁-C₆alkyl; R¹⁵ and R¹⁶ are independently selected from group, including -R¹⁸ and -YR¹⁸; where Y represents C₂-C₆alkenylene, and R¹⁸ is selected from group, including C₆-C₁₀aryl, benzo[1,3]dioxolyl, pyridinyl, pyrimidinyl, quinolyl, phenoxatiinyl, benzofuranyl, dibenzofuranyl, benzoxasolyl, 2,3-dihydrobenzofuranyl, 2-oxo-2,3-dihydrobenzooxasolyl, indolyl, 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazinyl, 2,3-dihydrobenzo[1,4]dioxinyl, 3,4-dihydro-2H-benzo[b][1,4]dioxepinyl, where any C₆-C₁₀aryl, pyridinyl, benzoxasolyl, indolyl in R¹⁸ is optionally substituted by 1-2 radicals, independently selected from group, including halogen, nitrogroup, cyanogroup, C₁-C₆alkyl, C₁-C₆alkoxygroup, C₁-C₆alkylthiogroup, hydroxy-C₁-C₆alkyl, halogen-substituted C₁-C₆alkyl, halogen-substituted C₁-C₆alkoxygroup, piperidinyl, morpholinyl, pyrrolidinyl, phenyl, XS(O)_0-2R¹⁷, -XNR¹⁷R¹⁷, -XNR¹⁷S(O)₂R¹⁷, -XNR¹⁷C(O)R¹⁷, -XC(O)NR¹⁷R¹⁷, -XC(O)NR¹⁷R¹⁹, -XC(O)R¹⁷, -XC(O)R¹⁹ and -XOXR¹⁹, where X represents bond; R¹⁷ is selected from group, including hydrogen, C₁-C₆alkyl, halogen-substituted C₁-C₆alkyl, and R¹⁹ is selected from group, including C₃-C₁₂cycloalkyl, phenyl, piperidinyl, morpholinyl.

EFFECT: ensuring application of invention compounds for production of medication, modulating activity of activated receptors of peroxisome proliferators δ (ARPPδ), to pharmaceutical composition, possessing properties of ARPPδ activity modulator, including therapeutically efficient quantity of invention compound and to application of pharmaceutical composition for medication manufacturing.

8 cl, 1 tbl, 301 ex