DIAGNOSTIC TECHNIQUE FOR PNEUMATIC HAMMER DIASEASE (PHD) IN MINERS Russian patent published in 2011 - IPC A61K38/22 A61K31/10 A61K31/45 A61P25/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to functional diagnostics. Capillaroscopy of nail-bed vessels of both fourth fingers is involved prior to and after pharmacological tests. A first pharmacological test is conducted by application of a mediator containing adrenaline in concentration 10^-5 mol/l mixed with dimethyl sulfoxide taken in the ratio 1:1 on one hand. Vasoconstriction time t₁ and vascular tone recovery time t₂ are determined. The mediator is removed by wiping a nail bed with 70% ethanol. A second pharmacological test is conducted by application of a mediator containing acetylcholine in concentration 10^-5 mol/l mixed with dimethyl sulfoxide taken in the ratio 1:1 on the other hand. Vasodilatation time t₃ and vascular tone recovery time t₄ are determined. The mediator is removed by wiping a nail bed with 70% ethanol. If the value t₁ is 2 to 5 seconds, t₂ is 20 to 44 seconds, t₃ is 8 to 15 seconds and t₄ is 16 to 25 sec, the degree I PHD is diagnosed, while the values t₂ 45 to 65 seconds and t₄ 10 to 15 sec enables to diagnose the degree II PHD.

EFFECT: technique allows improving diagnostic accuracy of the PHD severity in miners that is ensured by detection of endothelial dysfunctions directly in local vibration action points.

1 tbl, 2 ex