METHOD FOR ASSESSING BLOOD FLOW STATE IN HEALTHY INDIVIDUALS WITH CARDIOVASCULAR RISK FACTORS AND IN CARDIOVASCULAR PATIENTS Russian patent published in 2014 - IPC A61B5/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, specifically cardiology. A contour analysis of a pulse wave recorded by photoplethysmography is conducted in individuals being tested. A rigidity index is used to assess the state of a greater vascular wall. If the rigidity index is more than 8 m/s, the structural changes of the great vascular wall (Sk+) are recorded, and the rigidity index less than 8 m/s shows no structural changes of the greater vessels (Sk-). That is combined with a computer-assisted capillaroscopy of a periungual bed and dorsal finger skin. A capillary remodelling more than 1.33, rest capillary network density more than 45 drop/mm², as well as capillary network density after a venous occlusion test more than 56 drop/mm², show no structural changes of the microvessels (Sm-). If observing abnormal values of at least one parameter, the structural changes of the microvessels (Sm+) are stated. That is followed by an occlusion photoplethysmography to assess the functional changes of the greater vessels and microvasculature on the basis of a phase shift and an occlusion index. If the phase shift is less than 10 m/s, the functional disturbances of the greater vessels (Fk+), and the value more than 10 m/s shows no functional disturbances (Fk-). If the occlusion index is more than 1.8, the functional changes of the microvascular wall (Fm+) are stated, while the given value less than 1.8 shows no functional changes (Fm-). The structural-functional changes of the greater vessels, microvasculature and combinations thereof are detected to provide a basis to assess the blood flow state. A combination (Fk-Sk-; Fm-Sm-) show no disturbances of the blood flow considered as degree 0. The combination (Fk-Sk-; Fm+Sm-), (Fk+Sk-; Fm+Sm-), (Fk+Sk-; Fm-Sm-) provides considering the degree 1 blood flow involvement. The combinations (Fk-Sk+; Fm-Sm-) and (Fk+Sk+; Fm-Sm-) enables assessing the degree 2 involvement. The combinations (Fk-Sk+; Fm+Sm-) provide the degree 3 involvement. The combinations (Fk-Sk-; Fm-Sm-) and (Fk-Sk-; Fm+Sm+) provide stating the degree 4 involvement. The degree 5 blood flow involvement is shown by the combinations (Fk+Sk-; Fm-Sm+), (Fk-Sk+; Fm-Sm+), (Fk+Sk+; Fm-Sm+), (Fk+Sk-; Fm+Sm+), (Fk-Sk+; Fm+Sm+), (Fk+Sk+; Fm+Sm+), (Fk+Sk+; Fm+Sm-).

EFFECT: method enables the integrated assessment of the blood flow state at different levels to determine a version of the vascular wall changes and a degree of the blood flow involvement; they are highly specific, highly reproducible, non-invasive and have no contraindications, which creates an opportunity for more effective primary prevention of CVD.

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