2-SULPHANYLBENZIMIDAZOL-1-YL ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS Russian patent published in 2011 - IPC C07D235/28 A61K31/4164 A61P37/00 

FIELD: chemistry.

SUBSTANCE: invention relates to derivatives of general formula I, which can be used in treating prostaglandin mediated diseases,

where R¹, R², R³ and R⁴ independently denote hydrogen, alkyl, halogenalkyl, halogen, nitro, cyano, formyl, methylsulphonyl or methylcarbonyl; n is an integer from 0 to 5; r equals 0 or 1; R⁵, R⁶ and R⁷ independently denote hydrogen; alkyl; alkenyl; cyclohexyl; optionally substituted aryl, aryloxy; alkoxycarbonyl; phenylcarbonyl; N-alkyl-N-phenylcarbamoyl; N-alkyl-N-phenylalkylcarbamoyl; N-phenylalkyl-N-phenylcarbamoyl; optionally substituted furanyl, oxazolyl or pyridinyl; 1-alkoxycarbonylindazol-3-yloxy; 3,4-dihydro-2H-quinolin-1-ylcarbonyl; or a substituted amine; two of R⁵-R⁷ together with a carbon atom to which they are bonded form cycloakyl, substituted piperidinyl or pyrrolidinyl.

EFFECT: obtaining new biologically active compounds.

12 cl, 285 ex, 69 tbl