NOCICEPTIN ANALOGUES Russian patent published in 2011 - IPC C07D401/04 C07D235/26 C07D413/04 A61K31/4184 A61K31/454 A61K31/445 A61P25/04 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof , where D denotes phenyl; n equals 0; A, B and Q denote hydrogen; Z is selected from a group comprising a bond, straight C_1-3alkylene; R₁ is selected from a group comprising hydrogen, C_1-10alkyl, C_3-8cycloalkyl, benzyl, a 6-member monocyclic, 9-10-member bicyclic aromatic carbon-containing ring system and a spiro-ring system of formula (V): where X₁ and X₃ denote O; and where the said alkyl, cycloalkyl or benzyl from the R₁ group is optionally substituted with 1-3 substitutes selected from a group comprising C_1-3alkyl, cyano, phenyl, wherein the said phenyl is optionally substituted with 1-3 substitutes selected from halogen. The invention also relates to compounds of formulae .

Values of radicals of the said compounds are given in the claim. The invention also relates to a pharmaceutical composition having ORL1 receptor or µ opioid receptor inhibiting properties, containing an effective amount of the disclosed compound, a method of curing pain and a method of modulating pharmacological response from the opioid receptor, including the ORL1 or µ opioid receptor.

EFFECT: improved method.

41 cl, 5 tbl, 16 ex