DERIVATIVES OF BENZIMIDAZOLE AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF Russian patent published in 2005 - IPC

Abstract RU 2265018 C2

FIELD: organic chemistry, pharmacy.

SUBSTANCE: invention relates to derivatives of benzimidazole of general formulae (IV)

and

For compounds of the formula (IV): R represents hydrogen atom, (C₁-C₁₀)-alkyl and others; D represents phenyl or azaphenyl; n = 0; A, B and Q represent hydrogen atom, (C₁-C₁₀)-alkyl and others; Z represents a bond, (C₁-C₆)-alkylene or -CH₂O-; R₁represents hydrogen atom, (C₁-C₁₀)-alkyl and others; R₂ represents hydrogen atom. For compounds of the formula (IVA): n = 0; Z represents a bond, -CH₂-, -CH₂O-, -CH₂CH₂-; R represents hydrogen atom or (C₁-C₁₀)-alkyl; R₁ represents hydrogen atom, (C₃-C₁₂)-cycloalkyl, benzyl and others; R₂ represents hydrogen atom. Compounds of formulae (IV) and (IVA) possess affinity with respect to nociceptin and μ-receptors and can be used in medicine.

EFFECT: valuable medicinal properties of compounds.

18 cl, 5 tbl, 16 ex

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RU 2 265 018 C2

Authors

Sun Kun

Gering R. Richard

Kajl Donal'D

Chehn' Chzhehn'Min

Viktori Sehm

Uajtkhed Dzhon

Dates

2005-11-27—Published

2002-04-18—Filed