NOVEL SUBSTITUTED THIOPHENE PYRIMIDINONE DERIVATIVES AS 17β HYDROXYSTEROID DEHYDROGENASE INHIBITORS Russian patent published in 2011 - IPC C07D495/04 A61K31/519 A61P35/00 

Abstract RU 2409581 C2

FIELD: chemistry.

SUBSTANCE: invention describes novel compounds of formula where values of radicals are given in the formula of invention, and a pharmaceutically acceptable salt thereof. Said compounds have 17β-hydroxysteroid dehydrogenase enzyme (17β-HSD) inhibiting activity. The invention describes use of the formula (I) compound in treating or preventing diseases or disorders which require inhibition of 17β- hydroxysteroid dehydrogenase enzyme, use of the formula (I) compound to prepare a medicinal agent for treating or preventing diseases or disorders which require inhibition of 17β- hydroxysteroid dehydrogenase enzyme, and a pharmaceutical composition based on the formula (I) compound.

EFFECT: derivatives are highly effective.

18 cl, 7 tbl

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RU 2 409 581 C2

Authors

Khirvelja Lena

Khuzen Bettina

Kivinimi Ioganna

Koskimies Pasi

Lekhtovuori Pekka

Messinger Jozef

Pentikjainen Olli-Taneli

Pirkkala Lila

Sarenketo Pauli

Tole Genrikh-Khubert

Unkila Mikko

Van-Sten Bartolomeus Iokhannes

Dates

2011-01-20Published

2004-12-13Filed