1,3-DIHYDROBENZIMIDAZOL-2-YLIDEN AMINES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION Russian patent published in 2011 - IPC C07D401/06 C07D401/14 A61K31/4184 A61P11/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to novel derivatives of 1,3-dihydrobenzimidazol-3-ylidenamine of formula (I) and its additive salts, where each Alk independently represents C_1-6alkandiyl; Q represents hydrogen atom; C_1-6alkyl, substituted by one or two radicals Ar²; C_1-6alkyl, substituted by quinilinyl, morpholinyl or pyrrolidinonyl; -CO-Ar²; or Q represents radical, which has formula (a), where t can take value 2; R⁴ represents amino; R¹ represents morpholinyl, pyridyl or quinolinyl, where each of said monocyclic or bicyclic heterocycles can optionally have 2 substituents, selected from hydroxyl and C_1-6alkyl; R² represents Ar² or -CO-Ar² ; where Q is not hydrogen, R³ represents hydrogen atom; or where Q is hydrogen atom, R¹ represents hydrogen or morpholinyl and R³ represents radical which has formula (b), where R⁶ represents hydrogen atom; R⁷, R⁸ and R⁹ each independently, selected from C_1-6alkyl, R^10a-O-C_1-6alkyl; and R⁸ or R⁹ can also represent hydrogen atoms; R^10a represents hydrogen atom; Ar¹ represents phenyl; Ar² represents phenyl or phenyl substituted by 1,2 or 3 substituents, independently selected from halogen, hydroxy, C_1-6alkyl, cyano, nitro, hydroxy-C_1-6alkyl; polyhalogeno-C_1-6alkyl, C_1-6alkyloxyl, hydroxy-C_1-6alkyloxyl, C_1-6alkyloxycarbonyl, Ar¹ and Ar¹O. Invention also relates to pharmaceutical composition based on formula I compound and to method of obtaining formula I compounds.

EFFECT: obtained are novel derivatives of 1,3-dihydrobenzimidazole-2-yledenamine, which are RSV inhibitors.

10 cl, 5 tbl, 8 ex