STABLE SOLID DISPERSION OF VINCA ALKALOID DERIVATIVE AND METHOD FOR PRODUCING THEREOF Russian patent published in 2011 - IPC A61K8/04 A61K9/16 A61K9/48 A61K31/4375 

Abstract RU 2412687 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmacology and medicine, and represents a solid and stable oral dispersion of water-soluble Vinca alkaloid derivative, particularly vinorelbine in at least one polyethylene glycol of molecular weight within 1000 and 6000, wherein a mass ratio of water-soluble vinorelbine and more specifically, firstly vinorelbine ditartrate and, secondly polyethylene glycol is within 1.5:1 and 1:10 and, preferentially within 1:3 and 1:6.

EFFECT: invention provides higher stability of Vinca alkaloid derivatives, and especially vinorelbine salts, particularly vinorelbine ditartrate.

14 cl, 3 ex, 2 tbl, 2 dwg

Similar patents RU2412687C2

Title Year Author Number
STABLE PHARMACEUTICAL COMPOSITION OF WATER-SOLUBLE SALT OF VINORELBINE 2008
  • Pejjar Bruno
  • Avan Zhan-Lui
  • Bugare Zhoehl'
RU2476208C2
STABLE PHARMACEUTICAL COMPOSITION CONTAINING WATER-SOLUBLE VINFLUNINE SALT 2008
  • Pejjar Bruno
  • Avan Zhan-Lui
  • Bugare Zhoehl'
RU2462248C2
VINORELBIN-CONTAINING ORAL PHARMACEUTICAL COMPOSITION FOR SOFT CAPSULE AND METHOD FOR TREATMENT 2003
  • Bugare Zhoehl'
  • Lever Ehli
  • Bon Mari-Madlen
  • Khajntts Norbert
RU2279873C2
VINORELBINE MONOTARTRATE AND ITS PHARMACEUTICAL APPLICATION 2016
  • Zabudkin, Oleksandr
  • Matvienko, Viktor
  • Mata, Vladimir
  • Shikkaneder, Kristian
  • Matvienko, Yaroslav
  • Sypchenko, Vladimir
RU2730521C2
LYOPHILISED INJECTED PHARMACEUTICAL COMPOSTION OF SEMISYNTHETIC ALKALOIDS VINCA AND CARBOHYDRATES, STABLE AT ROOM TEMPERATURE 2007
  • Lever Ehli
  • Bugare Zhoehl'
  • Ibarra Mari-Dominik
RU2449791C2
PHARMACEUTICAL COMPOSITION BASED ON INDOMETHACIN MENTHYL ESTER IN FORM OF SOLID SELF-EMULSIFYING SYSTEM 2023
  • Shmykova Natalya Anatolevna
  • Stankevich Sergej Aleksandrovich
  • Khazanov Veniamin Abramovich
RU2823982C1
ORAL COMPOSITION COMPRISING DIFFICULTLY WATER-SOLUBLE ACTIVE SUBSTANCE SOLID SOLUTION 2003
  • Gorissen Khenrikus R. M.
RU2314811C2
PHARMACEUTICAL SOFT CAPSULES CONTAINING LYSINCHLONIXINATE, METHOD OF THEIR PREPARING 1993
  • Karlos E.M.Vaskes[Ar]
RU2108787C1
ORAL ANTITUMOUR DRUGS AND METHOD FOR ONCOLOGICAL DISEASES TREATMENT 2016
  • Shchekotikhin Andrej Egorovich
  • Treshchalina Elena Mikhajlovna
  • Treshchalin Ivan Dmitrievich
RU2639479C1
PHARMACEUTICAL SOFT GELATIN CAPSULE DOSAGE FORM WITH MODIFIED GUAR GUM 2014
  • Muldoon Brendan
  • Loughlin Ryan Gerald
  • Sweeney Gerarde
  • Boyd Emma Karen
RU2676480C2

RU 2 412 687 C2

Authors

Bugare Zhoehl'

Lever Ehli

Ibarra Mari-Dominik

Dates

2011-02-27Published

2005-12-20Filed