ORAL COMPOSITION COMPRISING DIFFICULTLY WATER-SOLUBLE ACTIVE SUBSTANCE SOLID SOLUTION Russian patent published in 2008 - IPC A61K31/55 A61K31/554 A61K47/26 A61K47/32 A61K47/34 A61K47/44 A61K9/48 

FIELD: pharmacy.

SUBSTANCE: invention proposes an oral composition for immediate release that comprises solid homogenous and thermodynamically stable solution of difficultly water-soluble solution of biologically active substance, a nonionogenic hydrophilic surface-active agent in liquid state at temperature 15-30°C in the amount 20-70% of the total composition mass, a pharmaceutically acceptable organic polymer or mixture of polymers in liquid state at temperature above 60°C and in solid state at temperature below 30°C in the amount 5-70% of the total composition mass and optionally a loosening agent in the amount 1-10% of the total composition mass. Indicated difficultly water-soluble active substance represents preferably 3-[[[1-[2-(ethoxycarbonyl)-4-phenylbutyl]cyclopentyl]carbonyl]amine]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid calcium salt. Invention provides improved bioavailability of active substance as compared with conventional medicinal formulation. The composition can be prepared by usual technology and equipment without large investments.

EFFECT: improved and valuable properties of composition, improved preparing method.

12 cl, 3 tbl, 6 dwg, 4 ex