PHARMACEUTICAL COMPOSITION BASED ON INDOMETHACIN MENTHYL ESTER IN FORM OF SOLID SELF-EMULSIFYING SYSTEM Russian patent published in 2024 - IPC A61K9/48 A61K31/33 A61K31/395 A61K31/403 A61K47/14 A61P29/00 

FIELD: pharmaceutical industry.

SUBSTANCE: group of inventions relates to a pharmaceutical composition characterized by anti-inflammatory action, a capsule containing said composition, and use of said pharmaceutical composition. A pharmaceutical composition characterized by anti-inflammatory action, containing: menthyl ester of indomethacin in amount of 5–25 wt.%, at least one tocopherol or a pharmaceutically acceptable salt thereof in amount of 0.5–2 wt.%, at least one medium-chain triglyceride in amount of 10–50 wt.%, at least one polyethylene glycol fatty acid ester with a melting point of 46–50°C in amount of 23–75 wt.%, wherein the ratio of medium-chain triglyceride and polyethylene glycol ester and fatty acids is in range of 1:2–1:3. Use of said pharmaceutical composition, characterized by anti-inflammatory action, for preparing an oral dosage form. Capsule characterized by anti-inflammatory action, containing said composition for oral administration.

EFFECT: use of the group of inventions provides the creation of a pharmaceutical composition in the form of a solid self-emulsifying system, which is characterized by high stability during storage at room temperature, bioavailability and anti-inflammatory activity and does not cause pronounced ulcerogenic action in therapeutic doses, is characterized by improved pharmacokinetic properties in terms of fast onset of effect and prolonged action profile with a single dose, composition is also suitable for making hard and soft gelatine capsules.

17 cl, 7 tbl, 5 ex