PYRAZOLE DERIVATIVES AND USE THEREOF AS RECEPTOR TYROSINE KINASE INHIBITORS Russian patent published in 2011 - IPC C07D403/12 C07D409/14 C07D495/04 C07D487/04 C07D471/04 C07D401/14 C07D417/04 C07D403/14 A61K31/506 A61P35/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to novel pyrazole derivatives of formula (I) or pharmaceutically acceptable salts thereof, having tyrosine kinase Trk inhibiting properties and used for treating or preventing malignant growths accompanied by high level of Trk, to a method of producing said derivatives, use thereof to prepare a medicinal agent, pharmaceutical compositions based on said derivatives, a method of inhibiting Trk activity and a method of obtaining antiproliferative action. where A denotes a single bond or C_1-2alkylene; where the said C_1-2alkylene can be optionally substituted with one R²²; ring C is a phenyl or a 5-6-member heterocyclic ring with 1-2 heteroatoms selected from N or S. Values of R¹-R⁷, R²² and n are given in the formula of invention.

EFFECT: obtaining pharmaceutically acceptable salts having tyrosine kinase Trk inhibiting properties and used for treating or preventing malignant growths.

20 cl, 5 dwg, 193 ex