CHEMICAL COMPOUNDS Russian patent published in 2010 - IPC C07D403/04 C07D473/34 C07D487/04 C07D471/04 A61K31/52 A61K31/519 A61K31/437 A61K31/4184 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to new compounds of formula (I): , in which: R¹ and R² are independently specified from hydrogen, C_1-6alkyl, C_1-6alkoxy and cyclopropyl; X¹, X² and X³ independently represent =N- or =CR¹⁰; R³ and R¹⁰ are independently specified from hydrogen, halogen, nitro, cyano, amino, carboxy, carbamoyl, C_1-6alkyl, N-(C_1-6alkyl)amino, N,N(C_1-6alkyl)₂amino, C_1-6alkanoylamino, C_1-6alkoxycarbonyl; R⁴ represents hydrogen; R⁵ and R⁶ are independently specified from hydrogen, hydroxy and C_1-6alkyl where R⁵ and R⁶ independently can be optionally substituted in carbon atom with one or more R¹⁶ where R¹⁶ represents hydroxy; A represents a single link or C_1-2alkylene; where specified C_1-2alkylene can be optionally substituted with one or more R¹⁸; the ring C represents a saturated, partially saturated or unsaturated mono- or bicyclic ring containing 5 or 6 atoms in which at least one atom can be specified from nitrogen, sulphur or oxygen which can be linked with carbon or nitrogen atom where the -CH₂- group can be optionally substituted with -C(O)- and ring sulphur atom can be optionally oxidised to produce S-oxide; R⁷ is specified from halogen and C_1-6alkyl where R⁷ can be optionally substituted in carbon atom with halogen; n is equal to 0.1 or 2; where R⁷ values can be equal or different; and R¹⁸ is independently specified from halogen and hydroxy; or its pharmaceutically acceptable salt. Also the invention refers to their pharmaceutical compositions and methods for preparation and application thereof for cancer treatment.

EFFECT: preparation of new compounds which can find application for cancer treatment.

23 cl, 96 ex