QUINOXALINE DERIVATIVES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of quinoxaline of the formula (I) where A - nitrogen or CH; R¹,R² - alkyl, halide or ; R⁴ - H, cycloalkyl or alkyl possibly substituted with hydroxy-, alkoxy-group, phenyl, pyridinyl, morpholinyl, benzimidazolyl, pyrazolyl, ozoxazol or phthalimidyl, C_2-6-alkenyl, C_2-6-alkynyl, C_2-6-alkanoyl, carboxy-group, aminoalkoxycarbonyl, alkylamino-, dialkylamino- -group, NHSO₂CF₃, CONR⁵R⁶, O(CH₂)_nNR⁵R⁶, NHCO-NR⁵R⁶;; R⁵, R⁶ - H, alkyl or in common with nitrogen atom form pyrrolidino- or morpholino-group; n = 2, 3 or 4, and their pharmaceutically acceptable salts that show anxiolytic, anticonvulsant, analgetic or neuroprotective activity. EFFECT: improved method of synthesis, valuable pharmacological activity. 15 cl, 3 tbl, 30 ex