METHOD FOR SIMULATING HYPERHOMOCYSTEIN INDUCED ENDOTHELIAL DYSFUNCTION Russian patent published in 2011 - IPC G09B23/28 

Abstract RU 2414755 C1

FIELD: medicine.

SUBSTANCE: hyperhomocytein induced endothelial dysfunction is simulated by intragastric introduction of amino acid methionine 3 g/kg to male Wistar rats once a day for 7 days. After methionine introduction completed, on the 8th day from the beginning of the experiment, the animals are anaesthetised to catheterise a left carotid artery to record haemodynamic values; bolus dosing of pharmacological agents (acetylcholine in a dose 40 mcg/kg, sodium nitroprusside in a dose 30 mcg/kg) is executed in a right femoral vein. The haemodynamic values are measured by an invasive sensor and Biopac computer program. A degree of endothelial dysfunction development is evaluated by an endothelial dysfunction coefficient. A degree of hyperhomocysteinemia development is evaluated by the homocystein content in blood serum of the experimental animals.

EFFECT: method provides development of an easily reproduced and toxicologically safe model of hyperhomocystein induced endothelial dysfunction.

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RU 2 414 755 C1

Authors

Emel'Janov Sergej Gennad'Evich

Korokin Mikhail Viktorovich

Pokrovskij Mikhail Vladimirovich

Kochkarov Vladimir Iskhakovich

Korokina Lilija Viktorovna

Pokrovskaja Tat'Jana Grigor'Evna

Gladchenko Mikhail Petrovich

Artjushkova Elena Borisovna

Gureev Vladimir Vladimirovich

Artjushkova Ekaterina Vjacheslavovna

Polonskaja Ksenija Vadimovna

Tsepelev Vasilij Jur'Evich

Gudyrev Oleg Sergeevich

Dates

2011-03-20Published

2009-10-19Filed