METHOD FOR L-NORVALINE CORRECTION OF HYPERHOMOCYSTEIN INDUCED NITROGEN OXIDE DEFICIENCY IN EXPERIMENT Russian patent published in 2012 - IPC G09B23/28 A61K31/195 A61P9/08 A61P9/10 A61P9/12 

FIELD: medicine.

SUBSTANCE: studying of mechanisms of correction and prevention of developing hyperhomocytein-induced nitrogen oxide deficiency in a body in experiment is ensured simulating nitrogen oxide deficiency in a laboratory animal by the intragastric introduction of methionine 3 g/kg daily within 7 days. A degree of developing deficiency is evaluated by the relation of endothelium-independent and endothelium-dependent vasodilation (EDV and EIDV). Nitrogen oxide deficiency is corrected by the intragastric introduction of L-norvaline 10 mg/kg 1 hour after the introduction of methionine for 7 days as well.

EFFECT: effective prevention of developing nitrogen oxide deficiency that proves to be true by the varying relation of the areas of blood pressure recovery accompanying endothelium-independent and endothelium-dependent vasodilation.

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