FIELD: medicine.
SUBSTANCE: invention refers to medicine, particularly to experimental cardiopharmacology and can be used for correction of endothelial dysfunction. It is ensured by simulation of endothelial dysfunction in experiment by intraperitoneal introduction to Wistar rats of N-nitro-L-arginine methyl ester dosed 25 mg/kg within 7 days. Thus the degree of dysfunction development is estimated by the relation of endothelium independent and endothelium dependent vasodilatation. Dysfunction is corrected by intraperitoneal introduction of preparation phosphogliv lyophilisate dosed 5.0 ml/kg and 0.5 ml/kg.
EFFECT: invention provides effective correction of endothelial dysfunction in specific experimental conditions.
2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF CORRECTION OF ENDOTHELIAL DYSFUNCTION BY PHOSPHOGLIV PREPARATION AT L-NAME INDUCED DEFICIENCY OF NITROGEN OXIDE | 2008 |
|
RU2359668C1 |
| METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH SOLVENT MIXTURE OF HOMEOPATHIC DILUTIONS OF POLYCLONAL RABBIT ANTIBODIES TO HUMAN ENDOTHELIAL NITROGEN OXIDE SYNTHASE C12, C30, C200 | 2006 |
|
RU2306953C1 |
| METHOD OF ENDOTHELIAL DYSFUNCTION CORRECTION BY COMBINATION OF TRIMETAZIDINE AND L-ARGININE IN L-NAME-INDUCED NITROGEN OXIDE DEFICIENCY | 2009 |
|
RU2421822C2 |
| METHOD OF CORRECTING ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF LOZARTAN AND RAZVERATROL IN CASES OF LONAME-INDUCED NITROGEN MONOXIDE DEFICIENCY | 2005 |
|
RU2306924C1 |
| METHOD FOR CORRECTING ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF INDAPAMIDE AND RESVERATROL AT L-NAME-INDUCED DEFICIENCY OF NITROGEN OXIDE | 2005 |
|
RU2302241C1 |
| METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION BY COMBINATION OF ENALAPRIL AND RESVERATROL IN L-NAME-INDUCED DEFICIENCY OF NITROGEN OXIDE | 2005 |
|
RU2301670C1 |
| METHOD OF TADALAFIL-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364395C1 |
| METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF INDAPAMIDE AND L-ARGININE IN L-NAME-INDUCED NITROGEN DEFICIT | 2005 |
|
RU2306929C1 |
| METHOD OF ACETYLSALICYLIC ACID BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364392C1 |
| METHOD OF CLOPIDOGREL-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364394C1 |
