FIELD: medicine.
SUBSTANCE: for correction of hyperhomocysteine-induced endothelial dysfunction in white rat males of Wistar line modeled is endothelial dysfunction by intragastric introduction of methionine in dose 3 g/kg daily during 7 days. Degree of dysfunction development is estimated by ratio of indices of endothelium-independent and endothelium-dependent vasodilatation, as well as by increase of homocysteine concentration. Correction of endothelial dysfunction is carried out by intragastric introduction of medication "Phosphogliv" capsules in dose 2.2 g/kg once per day an hour after methionine introduction.
EFFECT: method insures study of correction of hyperhomocysteine-induced endothelial dysfunction by means of phosphogliv with creation of definite model of said pathology.
2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR SIMULATING HYPERHOMOCYSTEIN INDUCED ENDOTHELIAL DYSFUNCTION | 2009 |
|
RU2414755C1 |
| METHOD FOR L-NORVALINE CORRECTION OF HYPERHOMOCYSTEIN INDUCED NITROGEN OXIDE DEFICIENCY IN EXPERIMENT | 2010 |
|
RU2453001C1 |
| METHOD OF CORRECTING HYPERHOMOCYSTEIN-INDUCED ENDOTHELIAL DYSFUNCTION BY MIXTURE OF SOLUTIONS OF HOMEOPATHIC DILUTIONS OF POLYCLONAL RABBIT ANTIBODIES TO HUMAN ENDOTHELIAL NITROGEN OXIDE SYNTHASE- C12, C30, C200 | 2010 |
|
RU2425672C1 |
| METHOD OF CORRECTION OF ENDOTHELIAL DYSFUNCTION BY PHOSPHOGLIV PREPARATION AT L-NAME INDUCED DEFICIENCY OF NITROGEN OXIDE | 2008 |
|
RU2359668C1 |
| METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH PREPARATION PHOSPHOGLIV LYOPHILIZATE IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY | 2008 |
|
RU2372078C1 |
| METHOD OF ENDOTHELIAL DYSFUNCTION CORRECTION BY COMBINATION OF TRIMETAZIDINE AND L-ARGININE IN L-NAME-INDUCED NITROGEN OXIDE DEFICIENCY | 2009 |
|
RU2421822C2 |
| METHOD OF TADALAFIL-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364395C1 |
| METHOD OF CLOPIDOGREL-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364394C1 |
| METHOD OF ACETYLSALICYLIC ACID BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364392C1 |
| METHOD FOR HYPOESTROGEN-INDUCED ENDOTHELIAL DYSFUNCTION CORRECTION WITH ENALAPRIL IN COMPLEX WITH MIXED SOLUTIONS OF HOMOEOPATHIC DILUTIONS OF POLYCLONAL RABBIT C12, C30, C200 ANTIBODIES TO HUMAN ENDOTHELIAL NITROGEN OXIDE SYNTHASE | 2010 |
|
RU2438189C1 |
