4-PIPERAZIN-1-YL-4-BENZO[b]THIOPHENE DERIVATIVES, SUITABLE FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS Russian patent published in 2011 - IPC C07D409/12 C07D333/54 C07D407/12 C07D413/12 A61K31/559 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a heterocyclic compound or salt thereof, having formula (1): where R² is hydrogen or a lower alkyl group; A is a lower alkylene group or a lower alkenylene group and R¹ is a cyclo(C₃-C₈)alkyl group, an aromatic group or a heterocyclic group selected from a group consisting of groups (I)-(IV), defined in the formula of invention. The invention also relates to a pharmaceutical composition, having activity as a partial agonist of dopamine D₂ receptors and/or a serotonin 5-HT_2A receptor antagonist and/or an adrenalin α₁ receptor antagonist and/or a serotonin absorption inhibitor and/or serotonin reuptake inhibitor based on said compounds, a method of preparing a pharmaceutical composition, use of said compounds as a partial agonist of dopamine D₂ receptors and/or a serotonin 5-HT_2A receptor antagonist and/or an adrenalin α₁ receptor antagonist and/or a serotonin absorption inhibitor and/or serotonin reuptake inhibitor, as well as a method of producing formula I compounds.

EFFECT: novel compounds are obtained and described, which have a wide range of curative effect on mental disorders, including central nervous system disorders, without side effects and with high degree of safety.

22 cl, 3110 ex, 314 tbl