INDOLE COMPOUND AND USE THEREOF Russian patent published in 2011 - IPC C07D209/18 A61P9/00 A61P11/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of general formula (1a-1a), where V^a denotes , , ,, W^A denotes -O-(C_1-6alkylene)-O-, -O- (C_2-6alkenylene) O-, -O-(C_1-6alkylene)-C(=O)-, -O-(C_1-7alkylene) or - (C_1-7alkylene)-O-; D^A denotes , , , , , , or , E^A denotes , , , ,

, m-1 equals 0 or denotes an integer from 1 to 3, w equals 0-5; R⁵ denotes H, -OH, CH₃, C₂H₅, C₃H₇, n-C₄H₉, n-C₅H₁₁, n-C₆H₁₃, -F, Cl, Br, -OCH₃, -OC₂H₅, -OC₃H₇, -OC₄H₉, acetyl, propanoyl, -CF₃, -S-CH₃; R^z denotes CH₃, C₂H₅, C₃H₇, C₄H₉, i-C₄H₉, -C₅H₁₁, -CF₃, alkyl, Ph, -OH, -OCH₃, -OC₂H₅, -F, CI, Br, I, acetyl, propanoyl; R¹¹ denotes (1) CH₃, C₂H₅, n-C₃H₇, i-C₃H₇, n-C₄H₉, i-C₄H₉, fluoro-C₄H₉, t-C₄H₉ -C₅H₁₁, C₆H₁₃, (4)-OH, which can be protected by CH₃, C₂H₅, n-C₃H₇, i-C₃H₇, n-C₄H₉, i-C₄H₉, fluoro-C₄H₉, t-C₄H₉, -C₅H₁₁, C₆H₁₃, (15) halogen; or pharmaceutically acceptable salt thereof.

EFFECT: compounds have antagonistic effect on the leukotriene receptor, which enables their use as a medicinal agent for preventing or treating leukotriene receptor mediated disease.

10 cl, 8 dwg, 47 tbl, 107 ex