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2 473 542

(13)

(51)

IPC

C07D209/30(2006-01-01)

C07D209/34(2006-01-01)

C07D401/12(2006-01-01)

C07D413/06(2006-01-01)

C07D417/04(2006-01-01)

A61K31/404(2006-01-01)

(21) (22)

Application

2009141986/04, 2008-04-16

(24)

Start date

2008-04-16

(22)

Actual filing date

2008-04-16

(45)

Published

2013-01-27

(72)

Inventor

Ehlmor Stiven V.Sauehrs Ehndrju Dzh.Branko MilanSun SjaokhunVan SiluKhasvol'D Liza A.Van LehKanzer Aaron R.Park Chehol-MinUehndt Majkl D.Tao Chzhi-FuMadar Dehvid

(73)

Holder

Ehbbott Lehboretriz

7-SUBSTITUTED INDOLE Mcl-1 INHIBITORS Russian patent published in 2013 - IPC C07D209/30 C07D209/34 C07D401/12 C07D413/06 C07D417/04 A61K31/404

Abstract RU 2473542 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to 7-substituted indoles of formula I:

or their pharmaceutically acceptable salts wherein the values A¹, B¹, C¹, D¹, E¹, F¹, G¹, L are presented in cl. 1 of the patent claim.

EFFECT: compounds inhibit activity of anti-apoptotic protein Mc1-1 that enables using them in pharmaceutical compositions.

5 cl, 7 dwg, 2 tbl, 609 ex

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RU 2 473 542 C2

Authors

Ehlmor Stiven V.

Sauehrs Ehndrju Dzh.

Branko Milan

Sun Sjaokhun

Van Silu

Khasvol'D Liza A.

Van Leh

Kanzer Aaron R.

Park Chehol-Min

Uehndt Majkl D.

Tao Chzhi-Fu

Madar Dehvid

Dates

2013-01-27—Published

2008-04-16—Filed