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2 416 640

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IPC

C12N7/00(2006-01-01)

A61K39/145(2006-01-01)

(21) (22)

Application

2010100524/10, 2010-01-11

(24)

Start date

2010-01-11

(22)

Actual filing date

2010-01-11

(45)

Published

2011-04-20

(72)

Inventor

Kiseleva Irina Vasil'EvnaLarionova Natal'Ja ValentinovnaRudenko Larisa GeorgievnaAleksandrova Galina Ibragimovna

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Meditsinskikh Nauk Nauchno-Issledovatel'Skij Institut Ehksperimental'Noj Meditsiny Severo-Zapadnogo Otdelenija Ramn Szo Ramn)

VACCINE STRAIN OF A/17/BRISBANE/07/1 (H3N2) INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN Russian patent published in 2011 - IPC C12N7/00 A61K39/145

Abstract RU 2416640 C1

FIELD: medicine.

SUBSTANCE: A/17/Brisbane/07/1 (H3N2) strain replicates actively in growing chicken embryos at optimum temperature 32°C. A reassortant has inherited the genes coding surface virus antigens - hemagglutinin (HA) and neuraminidase (NA) from an epidemic parent virus. The other six genes coding internal non-glycosylated proteins have been inherited from an attenuation donor. The A/17/Brisbane/07/1 (H3N2) strain is areactogenic for adults and children in intranasal introduction. The invention can be used in practical health services for preventing seasonal influenza incidence in adults and children by a live influenza intranasal vaccine of the A/17/Brisbane/07/1 (H3N2) strain.

EFFECT: strain is characterised by thermal sensitivity and cold adaptation.

1 dwg, 3 tbl

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RU 2 416 640 C1

Authors

Kiseleva Irina Vasil'Evna

Larionova Natal'Ja Valentinovna

Rudenko Larisa Georgievna

Aleksandrova Galina Ibragimovna

Dates

2011-04-20—Published

2010-01-11—Filed