FIELD: medicine.
SUBSTANCE: vaccine strain of A/17/Solomon Islands/06/9 (H1N1) is a reassortant prepared by cross breeding an epidemic A/Solomon Islands/03/2006 (H1N1) virus and a cold-adapted thermally sensitive A/Leningrad/134/17/57 (H2N2) virus being a human-safe attenuation donor. The vaccine strain A/17/Solomon Islands/06/9 (H1N1) strain replicates actively in growing chicken embryos at optimum temperature 32°C, is characterised by thermal sensitivity and cold adaptation, The reassortant has inherited the genes coding surface virus antigens - hemagglutinin (HA) and neuraminidase (NA) from an epidemic parent virus, and six genes coding internal non-glycosylated proteins from the attenuation donor. The A/17/Solomon Islands/06/9 strain is areactogenic for adults and children in intranasal introduction.
EFFECT: applicability in practical health services for preventing seasonal influenza incidence in adults and children by a live influenza intranasal vaccine of the strain of said influenza virus.
1 dwg, 3 tbl, 2 ex
